The current ‗prohibited list‘ includes hundreds of substances, ranging from volatile stimulants to modified polysaccharides and glycoproteins, considering also an increasing variety of doping methods, including blood transfusions and other forms of blood doping. The period of invisibility depends on many parameters, and can range from a few days to several years; to tell the truth, new invisible substances and methods are expected to ‗show up‘ in the future but as far as the scientific and technologic development continues to progress, and as far as the antidoping scientists continue to be involved in research projects running parallel to their routine activity, none of the few forms of doping will remain undetectable forever. The antidoping laboratories keep pace with the evolving scenario of doping substances and methods.