he aim of this study was to find out the relationship of Depression with Self-Esteem and Satisfaction with life among college students. Hundred male college students were considered for this study from different district of West Bengal whose age range from 20 to 25 years. The Rosenberg Self-Esteem Scale, the Satisfaction with Life Scale (SLS), and the Center for Epidemiologic Studies Depression Scale (CES-D) were used for collecting data. Pearson product moment Correlation Coefficient statistics was used to find out the relationship of Depression with Self-Esteem and Satisfaction with life among college students. In conclusion this study showed significant negative relationships of Depression with life satisfaction as well as with self-esteem among college students.